Background free in vivo29Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

Seung-Hyun Yang; Jiwon Kim; Tae Geol Lee; Mirae Park; Hye Young Son; Chan Gyu Joo; Jeong Hyun Shim; Youngbok Lee; Yong-Min Huh

doi:10.1039/D3AN01395B

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Background free in vivo²⁹Si MR imaging with hyperpolarized PEGylated silicon nanoparticles†

Seung-Hyun Yang,‡^ad Jiwon Kim,‡^b Tae Geol Lee,^c Mirae Park,^a Hye Young Son,^ad Chan Gyu Joo,^e Jeong Hyun Shim,*^c Youngbok Lee

*^bf and Yong-Min Huh*^adg

Author affiliations

* Corresponding authors

^a Department of Radiology, College of Medicine, Yonsei University, Seoul, Republic of Korea
E-mail: YMHUH@yuhs.ac

^b Department of Bionano Technology, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, Republic of Korea
E-mail: yblee@hanyang.ac.kr

^c Korea Research Institute of Standards and Science, Daejeon, Republic of Korea
E-mail: jhshim@kriss.re.kr

^d YUHS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul, Republic of Korea

^e Severance Biomedical Science Institute, College of Medicine, Yonsei University, Seoul, Republic of Korea

^f Department of Applied Chemistry, Hanyang University, Ansan, Republic of Korea

^g Department of Biochemistry & Molecular Biology, College of Medicine, Yonsei University, Seoul, Republic of Korea

Abstract

This study demonstrated the potential of 50 nm PEGylated Si NPs for high-resolution in vivo²⁹Si MR imaging, emphasizing their biocompatibility and water dispersibility. The acquisition of in vivo Si MR images using the lowest reported dose after subcutaneous and intraperitoneal administration opens new avenues for future ²⁹Si MR studies.

This article is part of the themed collection: Analyst HOT Articles 2023

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Article information

DOI: https://doi.org/10.1039/D3AN01395B
Article type: Communication
Submitted: 15 août 2023
Accepted: 22 sept. 2023
First published: 22 sept. 2023

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Analyst, 2023,148, 5355-5360

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Background free in vivo²⁹Si MR imaging with hyperpolarized PEGylated silicon nanoparticles

S. Yang, J. Kim, T. G. Lee, M. Park, H. Y. Son, C. G. Joo, J. H. Shim, Y. Lee and Y. Huh, Analyst, 2023, 148, 5355 DOI: 10.1039/D3AN01395B

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