A review on in vitro/in vivo response of additively manufactured Ti–6Al–4V alloy

Saeid Alipour; Shirin Nour; Seyyed Morteza Attari; Mohammad Mohajeri; Sogol Kianersi; Farzaneh Taromian; Mohammadparsa Khalkhali; George E. Aninwene; Lobat Tayebi

doi:10.1039/D2TB01616H

A review on in vitro/in vivo response of additively manufactured Ti–6Al–4V alloy

Saeid Alipour,^a Shirin Nour,^bc Seyyed Morteza Attari,

^d Mohammad Mohajeri,^e Sogol Kianersi,^f Farzaneh Taromian,^g Mohammadparsa Khalkhali,

^g George E. Aninwene, II^hij and Lobat Tayebi

*^k

Author affiliations

* Corresponding authors

^a Department of Materials Science and Engineering, Missouri University of Science and Technology, Rolla, MO 65409, USA

^b Tissue Engineering Group, Department of Biomedical Engineering, University of Melbourne, VIC 3010, Australia

^c Polymer Science Group, Department of Chemical Engineering, University of Melbourne, VIC 3010, Australia

^d Department of Material Science and Engineering, University of Connecticut, Storrs, Connecticut, USA

^e Department of Biomedical Engineering, College of Engineering, Texas A&M University, TX, USA

^f CÚRAM, SFI Centre for Research in Medical Devices, Biomedical Sciences, University of Galway, Galway, Ireland

^g Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran

^h Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, California, USA

ⁱ Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, California, USA

^j California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, California, USA

^k School of Dentistry, Marquette University, Milwaukee, Wisconsin, USA
E-mail: lobat.tayebi@marquette.edu
Tel: +414-288-8383

Abstract

Bone replacement using porous and solid metallic implants, such as Ti-alloy implants, is regarded as one of the most practical therapeutic approaches in biomedical engineering. The bone is a complex tissue with various mechanical properties based on the site of action. Patient-specific Ti–6Al–4V constructs may address the key needs in bone treatment for having customized implants that mimic the complex structure of the natural tissue and diminish the risk of implant failure. This review focuses on the most promising methods of fabricating such patient-specific Ti–6Al–4V implants using additive manufacturing (AM) with a specific emphasis on the popular subcategory, which is powder bed fusion (PBF). Characteristics of the ideal implant to promote optimized tissue-implant interactions, as well as physical, mechanical/chemical treatments and modifications will be discussed. Accordingly, such investigations will be classified into 3B-based approaches (Biofunctionality, Bioactivity, and Biostability), which mainly govern native body response and ultimately the success in implantation.

This article is part of the themed collection: Journal of Materials Chemistry B Recent Review Articles

Journal of Materials Chemistry B

A review on in vitro/in vivo response of additively manufactured Ti–6Al–4V alloy

Abstract

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A review on in vitro/in vivo response of additively manufactured Ti–6Al–4V alloy

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