Issue 38, 2022

Stimuli-responsive delivery strategies for controllable gene editing in tumor therapeutics

Abstract

The CRISPR system has attracted significant attention due to its great potential in tumor therapy. Developing effective, precise and safe delivery vectors is a prerequisite for CRISPR applications. Some disease-related biological signals provide a rationale for the development of precise delivery vehicles for stimuli-response delivery. Therefore, combining the linker of endogenous signal and exogenous signal stimulus responses with the nanocarrier is the key to designing and synthesizing the controllable release vector in stimuli-response delivery. This review summarizes the synthesis of stimuli-responsive nanocarriers by designing key chemical structures to achieve controllable release. Nanocarriers controlled by biochemical or physical signals are then discussed. Finally, potential challenges and prospects for existing nanocarriers are discussed.

Graphical abstract: Stimuli-responsive delivery strategies for controllable gene editing in tumor therapeutics

Article information

Article type
Review Article
Submitted
18 mai 2022
Accepted
10 août 2022
First published
12 août 2022

J. Mater. Chem. B, 2022,10, 7694-7707

Stimuli-responsive delivery strategies for controllable gene editing in tumor therapeutics

Y. Ji, L. Fan, S. Qu and X. Han, J. Mater. Chem. B, 2022, 10, 7694 DOI: 10.1039/D2TB01055K

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