Perspectives on parity violation in chiral molecules: theory, spectroscopic experiment and biomolecular homochirality

Abstract

The reflection (or ‘mirror’) symmetry of space is among the fundamental symmetries of physics. It is connected to the conservation law for the quantum number parity and a fundamental ‘non-observable’ property of space (as defined by an absolute ‘left-handed’ or ‘right-handed’ coordinate system). The discovery of the violation of this symmetry – the non-conservation of parity or ‘parity violation’ – in 1956/1957 had an important influence on the further development of physics. In chemistry the mirror symmetry of space is connected to the existence of enantiomers as isomers of chiral (‘handed’) molecules. These isomers would relate to each other as idealized left or right hand or as image and mirror image and would be energetically exactly equivalent with perfect space inversion symmetry. Parity violation results in an extremely small ‘parity violating’ energy difference between the ground states of the enantiomers which can be theoretically calculated to be about 100 aeV to 1 feV (equivalent to 10⁻¹¹ to 10⁻¹⁰ J mol⁻¹), depending on the molecule, but which has not yet been detected experimentally. Its detection remains one of the great challenges of current physical–chemical stereochemistry, with implications also for fundamental problems in physics. In biochemistry and molecular biology one finds a related fundamental question unanswered for more than 100 years: the evolution of ‘homochirality’, which is the practically exclusive preference of one chiral, enantiomeric form as building blocks in the biopolymers of all known forms of life (the L-amino acids in proteins and D-sugars in DNA, not the reverse D-amino acids or L-sugars). In astrobiology the spectroscopic detection of homochirality could be used as strong evidence for the existence of extraterrestrial life, if any. After a brief conceptual and historical introduction we review the development, current status, and progress along these three lines of research: theory, spectroscopic experiment and the outlook towards an understanding of the evolution of biomolecular homochirality.