Issue 73, 2022

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

Graphical abstract: Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Supplementary files

Article information

Article type
Communication
Submitted
28 avr. 2022
Accepted
05 août 2022
First published
08 août 2022

Chem. Commun., 2022,58, 10162-10165

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

L. Huang, P. K. Leung, L. C. Lee, G. Xu, Y. Lam and K. K. Lo, Chem. Commun., 2022, 58, 10162 DOI: 10.1039/D2CC02405E

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