Issue 3, 2021

A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection

Abstract

A near-infrared fluorescent probe (AH+) has been prepared by incorporating an oxazolidine switch into a near-infrared hemicyanine dye. The probe shows fast and sensitive responses to pH from an oxazolidine switch to the hemicyanine dye upon pH decreases from 10.0 to 5.0. The probe shows good photostability, low cytotoxicity, and reversible fluorescence responses to pH changes with a pKa value of 7.6. It has been successfully used to determine pH changes in mitochondria.

Graphical abstract: A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection

Supplementary files

Article information

Article type
Paper
Submitted
08 sept. 2020
Accepted
30 nov. 2020
First published
08 déc. 2020

J. Mater. Chem. B, 2021,9, 857-863

A near-infrared fluorescent probe based on a hemicyanine dye with an oxazolidine switch for mitochondrial pH detection

W. Mazi, Y. Yan, Y. Zhang, S. Xia, S. Wan, M. Tajiri, R. L. Luck and H. Liu, J. Mater. Chem. B, 2021, 9, 857 DOI: 10.1039/D0TB02181D

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