Issue 16, 2021

Triple-responsive targeted hybrid liposomes with high MRI performance for tumor diagnosis and therapy

Abstract

Targeted multi-responsive drug delivery systems with magnetic resonance imaging (MRI) capacity were anticipated as a promising tool for tumor therapy and diagnosis. Herein, we successfully synthesized anisamide-modified and non-modified UV/GSH-responsive molecules (10,10-NB-S-S-P-AA and 10,10-NB-S-S-P-OMe), and celecoxib-modified and non-modified UV/H2O2-responsive molecules (10,10-NB-OA-P-CE and 10,10-NB-OA-P-OMe). The targeted MRI-tracing UV/GSH/H2O2 triple-responsive hybrid liposomes (GNSOPAC) were fabricated by mixing with contrast agent (12,12-NB-DTPA-Gd), 10,10-NB-S-S-P-AA, and 10,10-NB-OA-P-CE in an optimal ratio of 6 : 1 : 1. GNSOPAC liposomes presented high DEE (>60%), favorable stability, good biocompatibility, and superior MRI performance. By MR imaging and fluorescence distribution in vivo, targeted drug-loaded liposomes (GNSOPACD) exhibited superior targeting activity than non-targeted drug-loaded liposomes (GNSOPMD) in the in vitro and in vivo studies. Compared with doxorubicin hydrochloride (DOX·HCl), the treatment of GNSOPACD + UV achieved a better anticancer effect in the in vitro and in vivo study, which may be related to the combined action of DOX·HCl, the celecoxib moiety and photolysis products. Moreover, GNSOPACD + UV exhibited negligible adverse effects during the in vivo treatment. Hence, anisamide and celecoxib co-modified UV/GSH/H2O2 triple-responsive hybrid liposomes with high MRI performance can act as a potential drug delivery system for tumor theranostics.

Graphical abstract: Triple-responsive targeted hybrid liposomes with high MRI performance for tumor diagnosis and therapy

Supplementary files

Article information

Article type
Research Article
Submitted
28 mai 2021
Accepted
28 juin 2021
First published
30 juin 2021

Mater. Chem. Front., 2021,5, 6226-6243

Triple-responsive targeted hybrid liposomes with high MRI performance for tumor diagnosis and therapy

W. Yao, C. Liu, N. Wang, H. Zhou, H. Chen and W. Qiao, Mater. Chem. Front., 2021, 5, 6226 DOI: 10.1039/D1QM00788B

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