Issue 44, 2021
From the journal:

Organic & Biomolecular Chemistry

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams†

Yi Zheng,‡a   Ting-Ting Zhang‡a  and  Wen-Bo Shen ORCID logo *a  

* Corresponding authors

a College of Sciences, Henan Agricultural University, Zhengzhou 450002, China
E-mail: wenboshen@henau.edu.cn

Abstract

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Graphical abstract: Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

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Article information

DOI
https://doi.org/10.1039/D1OB01846A
Article type
Paper
Submitted
17 sept. 2021
Accepted
22 oct. 2021
First published
22 oct. 2021

Org. Biomol. Chem., 2021,19, 9688-9691

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Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

Y. Zheng, T. Zhang and W. Shen, Org. Biomol. Chem., 2021, 19, 9688 DOI: 10.1039/D1OB01846A

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