Issue 87, 2021

An origami paper-based analytical device for DNA damage analysis

Abstract

Detection and characterization of DNA damage plays a critical role in genotoxicity testing, drug screening, and environmental health. We developed a fully integrated origami paper-based analytical device (oPAD) for measuring DNA damage. This simple device allows on-paper cell lysis, DNA extraction, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) reaction and signal readout with simple operation steps, enabling rapid (within 30 min) and high throughput assessment of multiple DNA damages induced by exogenous chemical agents.

Graphical abstract: An origami paper-based analytical device for DNA damage analysis

Supplementary files

Article information

Article type
Communication
Submitted
07 sept. 2021
Accepted
08 oct. 2021
First published
08 oct. 2021

Chem. Commun., 2021,57, 11465-11468

An origami paper-based analytical device for DNA damage analysis

W. Xue, Dan Zhao, Q. Zhang, Y. Chang and M. Liu, Chem. Commun., 2021, 57, 11465 DOI: 10.1039/D1CC05019B

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