Issue 98, 2021

Recent progress in the oxidative coupling of unactivated Csp3–H bonds with other C–H bonds

Abstract

The oxidative coupling between two carbon–hydrogen (C–H) bonds offers the most straightforward pathway to construct C–C bonds from hydrocarbons without pre-functionalization, exhibiting high step- and atom-economy. This article features the recent advances in the oxidative coupling of unactivated Csp3–H with different hybrid C–H bonds, including Csp–H, Csp2–H and Csp3–H bonds. The substrate scope, proposed mechanism and application of these reactions are summarized, intending to provide insights toward developing novel and efficient protocols for Csp3–C bond construction.

Graphical abstract: Recent progress in the oxidative coupling of unactivated Csp3–H bonds with other C–H bonds

Article information

Article type
Feature Article
Submitted
28 août 2021
Accepted
29 oct. 2021
First published
29 oct. 2021

Chem. Commun., 2021,57, 13288-13296

Recent progress in the oxidative coupling of unactivated Csp3–H bonds with other C–H bonds

Y. Liao, F. Liu and Z. Shi, Chem. Commun., 2021, 57, 13288 DOI: 10.1039/D1CC04802C

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