Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

Zhouyang Huang; A. Paden King; James Lovett; Barry Lai; Joshua J. Woods; Hugh H. Harris; Justin J. Wilson

doi:10.1039/D1CC04669A

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Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates†

Zhouyang Huang,

^a A. Paden King,^a James Lovett,

^b Barry Lai,^c Joshua J. Woods,

^ad Hugh H. Harris

^b and Justin J. Wilson

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA
E-mail: jjw275@cornell.edu

^b Department of Chemistry, The University of Adelaide, South Australia 5005, Australia

^c Advanced Photon Source, X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA

^d Robert F. Smith School for Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA

Abstract

The photophysical and photochemical properties of two Pt(IV)Re(I) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.

This article is part of the themed collection: 2021 Emerging Investigators

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DOI: https://doi.org/10.1039/D1CC04669A
Article type: Communication
Submitted: 21 août 2021
Accepted: 01 oct. 2021
First published: 08 oct. 2021

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Chem. Commun., 2021,57, 11189-11192

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Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

Z. Huang, A. P. King, J. Lovett, B. Lai, J. J. Woods, H. H. Harris and J. J. Wilson, Chem. Commun., 2021, 57, 11189 DOI: 10.1039/D1CC04669A

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Chemical Communications

Photochemistry and in vitro anticancer activity of Pt(iv)Re(i) conjugates†

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Photochemistry and in vitro anticancer activity of Pt(IV)Re(I) conjugates

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