Issue 70, 2021

Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes

Abstract

Radical fluoroalkylation of alkenes has been developed by electrochemical reduction of fluoroalkyl sulfones. A series of electron-deficient alkenes readily undergo hydrofluoroalkylation in good to excellent yields. This chemistry represents the first example of electrochemical generation of fluoroalkyl radicals from sulfones, which are used for practical radical fluoroalkylation of organic compounds.

Graphical abstract: Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes

Supplementary files

Article information

Article type
Communication
Submitted
19 juin 2021
Accepted
02 août 2021
First published
02 août 2021

Chem. Commun., 2021,57, 8750-8753

Electrochemical reduction of fluoroalkyl sulfones for radical fluoroalkylation of alkenes

X. Zhou, C. Ni, L. Deng and J. Hu, Chem. Commun., 2021, 57, 8750 DOI: 10.1039/D1CC03258E

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