Issue 22, 2020

Fast and easy conversion of ortho amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations

Abstract

DFT calculations performed on amidoaryldiselenides as electrophilic derivatives evidenced the presence of a prevalent Se⋯O weak interaction when selenium is bonded to a Se atom (diselenides), a Br atom (selenenyl bromide) and an O atom (selenenic acid), while for selenenyl iodide derivatives, a prevalent contribution of the Se⋯N interaction was predicted. This in silico observation has been experimentally exploited for the efficient synthesis of a small library of N-substituted benzoisoselenazol-3(2H)-ones and benzoisothiazol-3(2H)-ones considering the pharmacological relevance of ebselen recently reported also as an antiviral agent against Sars-Cov2.

Graphical abstract: Fast and easy conversion of ortho amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations

Supplementary files

Article information

Article type
Paper
Submitted
01 avr. 2020
Accepted
06 mai 2020
First published
07 mai 2020

New J. Chem., 2020,44, 9444-9451

Fast and easy conversion of ortho amidoaryldiselenides into the corresponding ebselen-like derivatives driven by theoretical investigations

V. Nascimento, P. S. Cordeiro, M. Arca, F. Marini, L. Sancineto, A. L. Braga, V. Lippolis, M. Iwaoka and C. Santi, New J. Chem., 2020, 44, 9444 DOI: 10.1039/D0NJ01605E

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