Issue 41, 2020

A supramolecular bifunctional iridium photoaminocatalyst for the enantioselective alkylation of aldehydes

Abstract

The construction of a hybrid metal-organo-photoredox catalyst based on the conjugation of an imidazolidinone organocatalyst and Ir(ppy)2(bipy) (ppy = 2-phenylpyridine, bipy = bipyridine) is described. The introduction of the desired organocatalyst into the bipyridine moiety is quite modular, allowing the preparation of different hybrid photocatalysts, and is realized though a simple click reaction. The hybrid photocatalysts obtained were employed in the benchmark photoredox alkylation of aldehydes. Remarkably, the conjugation of a first-generation MacMillan catalyst produces an active and stereoselective hybrid photoredox catalyst.

Graphical abstract: A supramolecular bifunctional iridium photoaminocatalyst for the enantioselective alkylation of aldehydes

Supplementary files

Article information

Article type
Paper
Submitted
22 juil. 2020
Accepted
23 sept. 2020
First published
12 oct. 2020

Dalton Trans., 2020,49, 14497-14505

A supramolecular bifunctional iridium photoaminocatalyst for the enantioselective alkylation of aldehydes

A. Gualandi, F. Calogero, A. Martinelli, A. Quintavalla, M. Marchini, P. Ceroni, M. Lombardo and P. G. Cozzi, Dalton Trans., 2020, 49, 14497 DOI: 10.1039/D0DT02587A

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