Autocatalytic DNAzyme assembly for amplified intracellular imaging

Keke Gong; Qiong Wu; Hong Wang; Shizhen He; Jinhua Shang; Fuan Wang

doi:10.1039/D0CC05257D

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Autocatalytic DNAzyme assembly for amplified intracellular imaging†

Keke Gong,‡^a Qiong Wu,‡^a Hong Wang,^a Shizhen He,^a Jinhua Shang^a and Fuan Wang

*^a

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* Corresponding authors

^a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: fuanwang@whu.edu.cn
Fax: +86-27-68756307
Tel: +86-27-68756307

Abstract

The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.

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DOI: https://doi.org/10.1039/D0CC05257D
Article type: Communication
Submitted: 01 août 2020
Accepted: 02 sept. 2020
First published: 02 sept. 2020

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Chem. Commun., 2020,56, 11410-11413

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Autocatalytic DNAzyme assembly for amplified intracellular imaging

K. Gong, Q. Wu, H. Wang, S. He, J. Shang and F. Wang, Chem. Commun., 2020, 56, 11410 DOI: 10.1039/D0CC05257D

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Chemical Communications

Autocatalytic DNAzyme assembly for amplified intracellular imaging†

Abstract

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Autocatalytic DNAzyme assembly for amplified intracellular imaging

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