Issue 70, 2020

Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

Abstract

Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed.

Graphical abstract: Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

Supplementary files

Article information

Article type
Communication
Submitted
28 mai 2020
Accepted
16 juil. 2020
First published
17 juil. 2020

Chem. Commun., 2020,56, 10127-10130

Rational design of a reversible Mg2+/EDTA-controlled molecular switch based on a DNA minidumbbell

L. Wan, S. L. Lam, H. K. Lee and P. Guo, Chem. Commun., 2020, 56, 10127 DOI: 10.1039/D0CC03774E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements