Issue 4, 2020
From the journal:

Chemical Communications

A fluorogenic probe for tracking GSH flux in developing neurons†

Haichao Zong,‡ab   Jiayi Peng,‡c   Xiao-Rong Li,c   Meng Liu,ab   Yongzhou Hu, ORCID logo c   Jia Li,ab   Yi Zang,*ab   Xin Li ORCID logo *c  and  Tony D. James ORCID logo d  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: yzang@simm.ac.cn

b University of Chinese Academy of Sciences, Beijing 100049, China

c College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
E-mail: lixin81@zju.edu.cn

d Department of Chemistry, University of Bath, Bath, UK

Abstract

Understanding GSH flux in developing neurons is prerequisite to reveal its role in neuronal development but necessiates an ultrasensitive assay. By systematically exploring key structural factors determing probe sensitivity in live cells, we developed a fluorogenic probe capable of imaging subtle GSH fluctuations in developing neurons.

Graphical abstract: A fluorogenic probe for tracking GSH flux in developing neurons

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Article information

DOI
https://doi.org/10.1039/C9CC07753G
Article type
Communication
Submitted
02 oct. 2019
Accepted
27 nov. 2019
First published
27 nov. 2019
This article is Open Access
Creative Commons BY license

Chem. Commun., 2020,56, 515-518

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A fluorogenic probe for tracking GSH flux in developing neurons

H. Zong, J. Peng, X. Li, M. Liu, Y. Hu, J. Li, Y. Zang, X. Li and T. D. James, Chem. Commun., 2020, 56, 515 DOI: 10.1039/C9CC07753G

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