Issue 2, 2019

Integrating reactive distillation with continuous flow processing

Abstract

A continuous flow platform has been developed that integrates reactive distillation with modern flow reactor technology. This has been applied to the successful flow synthesis of a series of tetrahydroquinolines generated through an InCl3-catalysed Povarov reaction between different aryl imines and cyclopentadiene that was generated by a continuous distillation from its dimeric precursor via a thermal retro Diels–Alder reaction. The developed continuous process represents a robust approach to these important heterocyclic entities which were prepared on the gram scale within less than one hour.

Graphical abstract: Integrating reactive distillation with continuous flow processing

Supplementary files

Article information

Article type
Paper
Submitted
28 sept. 2018
Accepted
30 nov. 2018
First published
30 nov. 2018

React. Chem. Eng., 2019,4, 368-371

Integrating reactive distillation with continuous flow processing

M. Baumann, React. Chem. Eng., 2019, 4, 368 DOI: 10.1039/C8RE00217G

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