Issue 7, 2019

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

Abstract

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were examined by UV-Vis, HPLC, CD spectroscopy, NMR, FID assays, EMSA and DLS. Our probe sets the basis for developing new optoepigenetic tools for conditional modulation of nucleosomal DNA accessibility.

Graphical abstract: ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

Supplementary files

Article information

Article type
Communication
Submitted
20 sept. 2018
Accepted
19 déc. 2018
First published
21 déc. 2018

Org. Biomol. Chem., 2019,17, 1827-1833

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

B. Heinrich, K. Bouazoune, M. Wojcik, U. Bakowsky and O. Vázquez, Org. Biomol. Chem., 2019, 17, 1827 DOI: 10.1039/C8OB02343C

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