Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis

Abstract

Duramycin derivatives incorporating an [¹⁸F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [¹⁸F]FP-digalacto-duramycin exhibited a low Log D, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo.