Development of a unique reversible fluorescent probe for tracking endogenous sulfur dioxide and formaldehyde fluctuation in vivo

Abstract

A reversible fluorescent probe (NP) for sensing SO₂ and FA was rationally constructed. With the outstanding attributes of NP, the fluctuation of endogenous SO₂ and FA was successfully traced, not only at the cellular level, but also in living mice for the first time. Significantly, it was first found that the interaction of SO₂ and FA can attenuate the cytotoxicity.