NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

Fei Yan; Xiangge Tian; Zhilin Luan; Lei Feng; Xiaochi Ma; Tony D. James

doi:10.1039/C8CC10311A

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury†

Fei Yan,‡^a Xiangge Tian,‡^a Zhilin Luan,^a Lei Feng,*^abc Xiaochi Ma

*^a and Tony D. James

*^b

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* Corresponding authors

^a Academy of Integrative Medicine, College of Pharmacy, Advanced Institute for Medical Sciences, Dalian Medical University, Lvshun South Road No. 9, Dalian 116044, P. R. China
E-mail: maxc1978@163.com, leifeng@mail.dlut.edu.cn

^b Department of Chemistry, University of Bath, Bath, BA2 7AY, UK
E-mail: t.d.james@bath.ac.uk

^c State Key Laboratory of Fine Chemicals, Dalian University of Technology, Ganjingzi District, Linggong Road No. 2, Dalian 116024, P. R. China

Abstract

We report an enzyme-activated fluorescence based probe (NHPO) for the selective detection of N-acetyl-β-D-glucosaminidase (NAG) activity in a drug-induced kidney injury mice model and NAG level in crude human urine. We used NHPO to explore the biological functions of NAG and provide a reference for the prognosis and prediction of proximal renal tubular dysfunction associated with various kidney diseases.

This article is part of the themed collection: The Mechanics of Supramolecular Chemistry

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DOI: https://doi.org/10.1039/C8CC10311A
Article type: Communication
Submitted: 31 déc. 2018
Accepted: 14 janv. 2019
First published: 14 janv. 2019
This article is Open Access

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Chem. Commun., 2019,55, 1955-1958

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NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

F. Yan, X. Tian, Z. Luan, L. Feng, X. Ma and T. D. James, Chem. Commun., 2019, 55, 1955 DOI: 10.1039/C8CC10311A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

NAG-targeting fluorescence based probe for precision diagnosis of kidney injury†

Abstract

Supplementary files

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NAG-targeting fluorescence based probe for precision diagnosis of kidney injury

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