Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Koushambi Mitra; Montserrat Samsó; Charles E. Lyons; Matthew C. T. Hartman

doi:10.1039/C8TB02533A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light†

Koushambi Mitra,

^ab Montserrat Samsó,^c Charles E. Lyons^b and Matthew C. T. Hartman

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA
E-mail: mchartman@vcu.edu

^b Massey Cancer Center, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA

^c Department of Physiology and Biophysics, 1101 E. Marshall St., Richmond, VA 23298, USA

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc–Pt–HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc–Pt–HA conjugate showed specific uptake, photo-enhanced cytotoxicity (∼1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

This article is part of the themed collection: International Year of the Periodic Table: Precious metals for cancer treatment

Download options Please wait...

Supplementary files

Supplementary information PDF (1571K)

Article information

DOI: https://doi.org/10.1039/C8TB02533A
Article type: Communication
Submitted: 26 sept. 2018
Accepted: 15 oct. 2018
First published: 24 oct. 2018

Download Citation

J. Mater. Chem. B, 2018,6, 7373-7377

Permissions

Request permissions

Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

K. Mitra, M. Samsó, C. E. Lyons and M. C. T. Hartman, J. Mater. Chem. B, 2018, 6, 7373 DOI: 10.1039/C8TB02533A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Journal of Materials Chemistry B

Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Hyaluronic acid grafted nanoparticles of a platinum(II)–silicon(IV) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Social activity

Search articles by author

Spotlight

Advertisements