Issue 34, 2018
From the journal:

RSC Advances

Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy†

Byung Woo Hwang,a   Young-Eun Kim, ORCID logo b   Mungu Kim,c   Seulgi Han,a   Seoyeon Bok,b   Kyeng Min Park,d   Annadka Shrinidhi,d   Ki Su Kim,ce   G-One Ahnb  and  Sei Kwang Hahn ORCID logo *ac  

* Corresponding authors

a Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Pohang 37673, Korea

b Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Pohang 37673, Korea

c PHI BIOMED Co., 175 Yeoksam-ro, Gangnam-gu, Seoul 06247, Korea

d Center for Self-assembly and Complexity (CSC), Institute for Basic Science (IBS), Pohang 37673, Republic of Korea

e Department of Organic Materials Science and Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Gumjeong-gu, Busan, Korea

Abstract

We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.

Graphical abstract: Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy

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Article information

DOI
https://doi.org/10.1039/C8RA00464A
Article type
Paper
Submitted
16 janv. 2018
Accepted
23 avr. 2018
First published
22 mai 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 18771-18775

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Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy

B. W. Hwang, Y. Kim, M. Kim, S. Han, S. Bok, K. M. Park, A. Shrinidhi, K. S. Kim, G. Ahn and S. K. Hahn, RSC Adv., 2018, 8, 18771 DOI: 10.1039/C8RA00464A

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