Issue 21, 2018

Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

Abstract

Transition metal-mediated modification of peptides and proteins is emerging as a powerful method for their selective functionalization and bioconjugation, particularly for native peptides and proteins bearing no unnatural bioorthogonal handles. The modified peptides and proteins are useful synthetic reagents needed in both biochemical and biophysical studies, as well as in pharmaceutical research. This mini-review surveys recent developments of regio- and chemoselective arylation reactions of the natural nucleophilic residues within unprotected peptides and proteins, promoted by arylpalladium complexes. These reactions exhibited high selectivities and excellent biocompatibility, proceeded under mild reaction conditions, and have a wide range of applications. They exemplify the advantages and potential of organometallic palladium complexes in bioconjugation, and are expected to inspire future studies on transition metal-mediated biocompatible modification reactions.

Graphical abstract: Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

Article information

Article type
Review Article
Submitted
31 juil. 2018
Accepted
07 sept. 2018
First published
21 sept. 2018

Org. Chem. Front., 2018,5, 3186-3193

Selective modification of natural nucleophilic residues in peptides and proteins using arylpalladium complexes

W. Cheng, X. Lu, J. Shi and L. Liu, Org. Chem. Front., 2018, 5, 3186 DOI: 10.1039/C8QO00765A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements