Issue 27, 2018
From the journal:

Organic & Biomolecular Chemistry

Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans†

Haizhou Lin,‡ab   Haining Lyu,‡a   Shuang Zhou,ab   Jingwen Yu,ab   Nancy P. Keller,c   Lin Chena  and  Wen-Bing Yin ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
E-mail: yinwb@im.ac.cn

b Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China

c Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, WI, USA

Abstract

By disruption of LaeB, a global regulator recently characterized in Aspergillus nidulans, eight cryptic compounds in the mutant were identified, including seven polyketides and one NRPS-like product. Among the isolates, two phthalides and two dibenzo[1,4]dioxins are new compounds, revealing that the genetic manipulation of the global regulator represents a promising approach for the discovery of novel natural products in fungi.

Graphical abstract: Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

  • This article is part of the themed collection: Biosynthesis
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Article information

DOI
https://doi.org/10.1039/C8OB01326H
Article type
Communication
Submitted
06 juin 2018
Accepted
19 juin 2018
First published
19 juin 2018

Org. Biomol. Chem., 2018,16, 4973-4976

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Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans

H. Lin, H. Lyu, S. Zhou, J. Yu, N. P. Keller, L. Chen and W. Yin, Org. Biomol. Chem., 2018, 16, 4973 DOI: 10.1039/C8OB01326H

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