Issue 1, 2018

Single nanoparticle analysis by ICPMS: a potential tool for bioassay

Abstract

Inductively coupled plasma mass spectrometry (ICPMS) has already been demonstrated as a promising technique for metallic nanoparticle tagged bioassays due to its high sensitivity, wide dynamic linear range, and more importantly multiplex and absolute quantification ability. Besides, single nanoparticle analysis by ICPMS has also recently been applied for many metal nanoparticles. Moreover, its short data acquisition dwell times (serval hundred microseconds) lead to an extremely high signal to noise ratio for metal nanoparticles (i.e., low detection limits). This perspective focuses on single nanoparticle analysis-based ICPMS bioassays, which provide high sensitivity without any sophisticated signal amplification procedures. Herein, the recent development of single nanoparticle analysis, ICPMS instrument design, and single molecule analysis is discussed. Considering the vast types of metallic nanoparticles currently available and simultaneous multiplex detection capability of TOF-ICPMS, single nanoparticle analysis-based bioassays may open a new avenue for multiplex single molecule analysis.

Graphical abstract: Single nanoparticle analysis by ICPMS: a potential tool for bioassay

Article information

Article type
Perspective
Submitted
27 juin 2017
Accepted
13 nov. 2017
First published
13 nov. 2017

J. Anal. At. Spectrom., 2018,33, 57-67

Single nanoparticle analysis by ICPMS: a potential tool for bioassay

J. Hu, D. Deng, R. Liu and Y. Lv, J. Anal. At. Spectrom., 2018, 33, 57 DOI: 10.1039/C7JA00235A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements