Electrochemical dehydrogenative cyclization of 1,3-dicarbonyl compounds

Abstract

The intramolecular C(sp³)–H/C(sp²)–H cross-coupling of 1,3-dicarbonyl compounds has been achieved through Cp₂Fe-catalyzed electrochemical oxidation. The key to the success of these dehydrogenative cyclization reactions is the selective activation of the acidic α-C–H bond of the 1,3-dicarbonyl moiety to generate a carbon-centered radical.