Copper-mediated regioselective C–H etherification of naphthylamides with arylboronic acids using water as an oxygen source

Abstract

The copper-mediated regioselective C–H activation and C–O bond formation of naphthylamides with arylboronic acids has been developed using water as an oxygen source. The kinetic isotope study suggests that C–H bond activation is the rate-determining step. The H₂O¹⁸ labelling experiment reveals the incorporation of oxygen from water. The substrate scope, functional group diversity and post synthetic utilities are the important practical features.