Issue 11, 2017

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Abstract

The N-demethylation of selected N-methylalkaloids using a modified Polonovski reaction can be accomplished using a novel green methodology employing nanoscale zero-valent iron, nZVI, in isopropanol. Use of nZVI promotes a much faster conversion to N-demethylated products due to much higher surface area on the metal surface as shown by SEM analysis. Rates of conversion can be further enhanced using catalytic quantities of the solubilised iron(0) species triiron dodecacarbonyl, Fe3(CO)12.

Graphical abstract: Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Supplementary files

Article information

Article type
Paper
Submitted
08 févr. 2017
Accepted
05 mai 2017
First published
09 mai 2017

Green Chem., 2017,19, 2587-2594

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

J. K. Awalt, R. Lam, B. Kellam, B. Graham, P. J. Scammells and R. D. Singer, Green Chem., 2017, 19, 2587 DOI: 10.1039/C7GC00436B

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