Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective

Yong-Yuan Gui; Li-Li Liao; Liang Sun; Zhen Zhang; Jian-Heng Ye; Guo Shen; Zhi-Peng Lu; Wen-Jun Zhou; Da-Gang Yu

doi:10.1039/C6CC09685A

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Coupling of C(sp³)–H bonds with C(sp²)–O electrophiles: mild, general and selective†

Yong-Yuan Gui,^a Li-Li Liao,^a Liang Sun,^a Zhen Zhang,^a Jian-Heng Ye,^a Guo Shen,^a Zhi-Peng Lu,^a Wen-Jun Zhou^ab and Da-Gang Yu

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China
E-mail: dgyu@scu.edu.cn

^b College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang 641112, P. R. China

Abstract

Herein is reported the mild and general coupling of amine/ether C(sp³)–H bonds with various kinds of C(sp²)–O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification.

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Article information

DOI: https://doi.org/10.1039/C6CC09685A
Article type: Communication
Submitted: 06 déc. 2016
Accepted: 23 déc. 2016
First published: 06 janv. 2017

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Chem. Commun., 2017,53, 1192-1195

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Coupling of C(sp³)–H bonds with C(sp²)–O electrophiles: mild, general and selective

Y. Gui, L. Liao, L. Sun, Z. Zhang, J. Ye, G. Shen, Z. Lu, W. Zhou and D. Yu, Chem. Commun., 2017, 53, 1192 DOI: 10.1039/C6CC09685A

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