Issue 9, 2016
From the journal:

Chemical Communications

Foldameric probes for membrane interactions by induced β-sheet folding†

Zsófia Hegedüs,‡a   Ildikó Makra,‡b   Norbert Imre,a   Anasztázia Hetényi,c   István M. Mándity,d   Éva Monostorib  and  Tamás A. Martinek*a  

* Corresponding authors

a Institute of Pharmaceutical Analysis, SZTE-MTA Lendület Foldamer Research Group, University of Szeged, H-6720 Szeged, Hungary
E-mail: martinek@pharm.u-szeged.hu

b Lymphocyte Signal Transduction Laboratory, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary

c Department of Medical Chemistry, University of Szeged, H-6720 Szeged, Hungary

d Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Hungary

Abstract

Design strategies were devised for α/β-peptide foldameric analogues of the antiangiogenic anginex with the goal of mimicking the diverse structural features from the unordered conformation to a folded β-sheet in response to membrane interactions. Structure–activity relationships were investigated in the light of different β-sheet folding levels.

Graphical abstract: Foldameric probes for membrane interactions by induced β-sheet folding

  • This article is part of the themed collection: Foldamers
About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC09257D
Article type
Communication
Submitted
08 nov. 2015
Accepted
10 déc. 2015
First published
10 déc. 2015

Chem. Commun., 2016,52, 1891-1894

Permissions

Request permissions

Foldameric probes for membrane interactions by induced β-sheet folding

Z. Hegedüs, I. Makra, N. Imre, A. Hetényi, I. M. Mándity, É. Monostori and T. A. Martinek, Chem. Commun., 2016, 52, 1891 DOI: 10.1039/C5CC09257D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements