Issue 25, 2015
From the journal:

Journal of Materials Chemistry B

Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery†

John G. Hardy,*ab   Megan N. Amend,b   Sydney Geissler,ab   Vincent M. Lynchc  and  Christine E. Schmidt*ab  

* Corresponding authors

a Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA

b J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Biomedical Sciences Building JG-53, P.O. Box 116131, Gainesville, FL 32611-6131, USA
E-mail: johnhardyuk@gmail.com, schmidt@bme.ufl.edu

c Department of Chemistry, The University of Texas at Austin, Austin, TX 78712, USA

Abstract

We report the preparation and characterization of films of electroactive supramolecular polymers based on non-electroactive oligoalanines and electroactive oligoanilines. Fibroblasts adhered to and proliferated on the films, and the delivery of the clinically relevant anti-inflammatory drug dexamethasone phosphate could be enhanced upon the application of an electrical stimulus.

Graphical abstract: Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

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Article information

DOI
https://doi.org/10.1039/C5TB00106D
Article type
Communication
Submitted
16 janv. 2015
Accepted
10 mars 2015
First published
08 juin 2015
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2015,3, 5005-5009

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Peptide-directed assembly of functional supramolecular polymers for biomedical applications: electroactive molecular tongue-twisters (oligoalanine–oligoaniline–oligoalanine) for electrochemically enhanced drug delivery

J. G. Hardy, M. N. Amend, S. Geissler, V. M. Lynch and C. E. Schmidt, J. Mater. Chem. B, 2015, 3, 5005 DOI: 10.1039/C5TB00106D

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