SERS-active silver nanoparticle trimers for sub-attomolar detection of alpha fetoprotein

Xiaoling Wu; Pan Fu; Wei Ma; Liguang Xu; Hua Kuang; Chuanlai Xu

doi:10.1039/C5RA12629K

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SERS-active silver nanoparticle trimers for sub-attomolar detection of alpha fetoprotein†

Xiaoling Wu,^a Pan Fu,^a Wei Ma,^a Liguang Xu,^a Hua Kuang^a and Chuanlai Xu*^a

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* Corresponding authors

^a State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, People's Republic of China
E-mail: xcl@jiangnan.edu.cn

Abstract

SERS-active silver nanoparticle trimers were assembled in this study for the first time, through the aptamer of a cancer biomarker, alpha fetoprotein (AFP). It was successfully used for the sub-attomolar detection of AFP, with a limit of detection as low as 0.097 aM, which is the lowest reported so far.

This article is part of the themed collection: Surface enhanced Raman Spectroscopy: Editors collection for RSC Advances

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DOI: https://doi.org/10.1039/C5RA12629K
Article type: Communication
Submitted: 30 juin 2015
Accepted: 21 août 2015
First published: 24 août 2015

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RSC Adv., 2015,5, 73395-73398

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SERS-active silver nanoparticle trimers for sub-attomolar detection of alpha fetoprotein

X. Wu, P. Fu, W. Ma, L. Xu, H. Kuang and C. Xu, RSC Adv., 2015, 5, 73395 DOI: 10.1039/C5RA12629K

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SERS-active silver nanoparticle trimers for sub-attomolar detection of alpha fetoprotein†

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