Issue 5, 2015

Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Abstract

The definition of crystal morphologies in polymorphic systems is a fundamental area of crystal engineering with implications for down-stream processing and formulation, which make morphological studies highly relevant. There are few recent examples of such detailed studies in the literature and here we address the case of p-aminobenzoic acid (PABA), focusing on its two polymorphic forms, α and β. Using a combination of modelling techniques to create predicted morphologies, we interpret these in the light of experimental data recorded on crystals grown from a range of polar solvents. Preliminary discussion of the intermolecular interactions involved in crystal growth of both forms, allow us to explore the enhanced morphological importance of the (002) face in α PABA and of (10[1 with combining macron]) and (0[1 with combining macron]1) faces for β PABA. It is suggested that desolvation plays a paramount role.

Graphical abstract: Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

Supplementary files

Article information

Article type
Paper
Submitted
11 sept. 2014
Accepted
23 oct. 2014
First published
30 oct. 2014

CrystEngComm, 2015,17, 1015-1023

Concerning the crystal morphologies of the α and β polymorphs of p-aminobenzoic acid

R. A. Sullivan and R. J. Davey, CrystEngComm, 2015, 17, 1015 DOI: 10.1039/C4CE01857E

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