Issue 7, 2015
From the journal:

Biomaterials Science

Engineering DNA scaffolds for delivery of anticancer therapeutics

Wujin Sunab  and  Zhen Gu*abc  

* Corresponding authors

a Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA

b Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
E-mail: zgu@email.unc.edu, zgu3@ncsu.edu

c Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA

Abstract

Engineering DNA nanostructures with programmability in size, shape and surface chemistry holds tremendous promise in biomedical applications. As an emerging platform for drug delivery, DNA nanostructures have been extensively studied for delivering anticancer therapeutics, including small-molecule drug, nucleic acids and proteins. In this mini-review, current advances in utilizing DNA scaffolds as drug carriers for cancer treatment were summarized and future challenges were also discussed.

Graphical abstract: Engineering DNA scaffolds for delivery of anticancer therapeutics

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Article information

DOI
https://doi.org/10.1039/C4BM00459K
Article type
Minireview
Submitted
29 déc. 2014
Accepted
13 févr. 2015
First published
25 févr. 2015

Biomater. Sci., 2015,3, 1018-1024

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Engineering DNA scaffolds for delivery of anticancer therapeutics

W. Sun and Z. Gu, Biomater. Sci., 2015, 3, 1018 DOI: 10.1039/C4BM00459K

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