Specific interactions between silver(I) ions and cytosine–cytosine pairs in DNA duplexes

Akira Ono; Shiqi Cao; Humika Togashi; Mitsuru Tashiro; Takashi Fujimoto; Tomoya Machinami; Shuji Oda; Yoko Miyake; Itaru Okamoto; Yoshiyuki Tanaka

doi:10.1039/B808686A

Specific interactions between silver(i) ions and cytosine–cytosine pairs in DNA duplexes†

Akira Ono,*^a Shiqi Cao,^b Humika Togashi,^b Mitsuru Tashiro,^c Takashi Fujimoto,^c Tomoya Machinami,^c Shuji Oda,^d Yoko Miyake,^b Itaru Okamoto^a and Yoshiyuki Tanaka^d

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* Corresponding authors

^a Department of Material & Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama, Japan
E-mail: akiraono@kanagawa-u.ac.jp
Fax: +81-45-491-7915
Tel: +81-45-481-5661(Ex3887)

^b Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Japan

^c Department of Chemistry, College of Science and Technology, Meisei University, Hino, Japan

^d Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Japan

Abstract

Very specific binding of the Ag(I) ion unexpectedly stabilized DNA duplexes containing the naturally occurring cytosine–cytosine (C–C) mismatch-base pair; because the C–C pair selectively binds to the Ag(I) ion, we developed a DNA-based Ag(I) sensor that employed an oligodeoxyribonucleotide containing C–C pairs used for Ag(I) binding sites.

This article is part of the themed collection: ChemComm 60th Anniversary Historic Papers from Japan and South Korea

Chemical Communications

Specific interactions between silver(i) ions and cytosine–cytosine pairs in DNA duplexes†

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Specific interactions between silver(I) ions and cytosine–cytosine pairs in DNA duplexes

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