Transition-state analogues based upon the 6-(hydroxymethyl)-13-azagona-1,3,5(10),8-tetraene structure (e.g., 40) have been designed and synthesized as part of a programme to elicit antibodies capable of catalysing cationic cyclisations. Methodology for conjugating such analogues to proteins has also been developed.
I. M. Bell, C. Abell and F. J. Leeper, J. Chem. Soc., Perkin Trans. 1, 1994, 1997 DOI: 10.1039/P19940001997
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