Ammonia surrogates in the synthesis of primary amines

Abstract

Primary amines are derivatives of ammonia in which one hydrogen atom is replaced by an alkyl or aryl group. Ammonia serves as the primary nitrogen source in amination reactions, and its utilization in solution or as a pure gas has witnessed notable advancements. However, the use of gaseous ammonia remains problematic in academic laboratory settings, while employing aqueous ammonia poses challenges in highly water-sensitive transformations. Consequently, the search for alternative sources of ammonia has garnered considerable attention among the organic chemistry community. This comprehensive literature review focuses on the use of ammonia surrogates in amination reactions, irrespective of the resulting intermediate. The review emphasizes the formation of the C–N bond and underscores the importance of generating intermediate products that can be readily transformed into primary amines through well-established reactions.