Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity

Dan Du; Yu-dun Liu; Jun-bing Lan; Xue-li Hou; Jia-dong Liu; Qing-hua Shi; Qing-wen Huang; Yun-sheng Xue; Chao-Guo Yan; Lin An

doi:10.1039/D3CC04102F

Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity†

Dan Du,‡^ab Yu-dun Liu,‡^ab Jun-bing Lan,^ab Xue-li Hou,^ab Jia-dong Liu,^ab Qing-hua Shi,^ab Qing-wen Huang,^ab Yun-sheng Xue,^ab Chao-Guo Yan

*^c and Lin An

*^ab

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* Corresponding authors

^a College of Pharmacy, Xuzhou Medical University, Xuzhou 221004, P. R. China

^b New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, P. R. China
E-mail: anlinhx@xzhmu.edu.cn

^c College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China
E-mail: cgyan@yzu.edu.cn

Abstract

Supramolecular carrier-mediated chemotherapy is a highly attractive strategy for targeted drug delivery. In this study, four novel biotin-linked calix[4]arenes BPCA1-BPCA4 have been rationally designed to construct nano-complex with doxorubicin. The in vitro and in vivo assessments reveal that BPCA4-DOX with excellent stability are capable of affording significantly superior anti-tumor activity and lower side effects.

This article is part of the themed collection: Supramolecular & Macrocyclic chemistry

Chemical Communications

Novel biotin-linked amphiphilic calix[4]arene-based supramolecular micelles as doxorubicin carriers for boosted anticancer activity†

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