Issue 14, 2022

Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

Abstract

Na2B12I12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical imaging. We demonstrate here that PBS solutions with >50 mM Na2B12I12 induce hemolysis, consistent with the previously reported superchaotropic nature of the anion. The presence of <1 equiv. of 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis and suggests a strategy for exploiting B12I122− as an X-ray contrast agent.

Graphical abstract: Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

Supplementary files

Article information

Article type
Communication
Submitted
11 nov. 2021
Accepted
19 janv. 2022
First published
19 janv. 2022

Chem. Commun., 2022,58, 2375-2378

Author version available

Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis

S. E. Hollow and T. C. Johnstone, Chem. Commun., 2022, 58, 2375 DOI: 10.1039/D1CC06348K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements