Issue 40, 2021

Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

Abstract

Matching of charge periodicity between a guest and a host enabled effective immobilization of highly water-soluble antibiotic drug, gentamicin C, in a bentonite clay by cation exchange. X-ray diffraction, infrared spectroscopy and CHNS analysis revealed the immobilization manner of gentamicin C, which was immobilized between bentonite layers via periodic charge–charge interaction with tilted arrangement, as a trication. Both gentamicin alone and a gentamicin/bentonite hybrid were coated onto a polyurethane substrate using water-borne polyurethane binder. The antibiotic character of both films was investigated as prepared or after immersion in phosphate-buffered saline till 5 days against E. coli and B. subtilis bacteria. It was clearly shown that the gentamicin/bentonite hybrid–coated film showed sustained antibacterial efficacy even after exposure to phosphate-buffered saline, while gentamicin only–coated film gradually lost its performance under the same condition.

Graphical abstract: Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

Article information

Article type
Paper
Submitted
31 juil. 2021
Accepted
06 sept. 2021
First published
06 sept. 2021

Dalton Trans., 2021,50, 14216-14222

Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

T. Yamaguchi, S. Ko, J. Jung, H. Kim and J. Oh, Dalton Trans., 2021, 50, 14216 DOI: 10.1039/D1DT02540F

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