Issue 95, 2021

Multichannel dual protein sensing using amphiphilic supramolecular assemblies

Abstract

Protein sensing strategies have implications in detection of many human pathologies. Here, a supramolecular strategy for sensing two different proteins using a multichannel readout approach is outlined. Protein–ligand binding or enzymatic cleavage can both be programmed to induce supramolecular disassembly, which leads to fluorescence enhancement via aggregation-induced emission (AIE), protein-induced fluorescence enhancement (PIFE), or disassembly-induced fluorescence enhancement (DIFE). The accompanying signal change from two different fluorophores and their patterns are then used for specific protein sensing.

Graphical abstract: Multichannel dual protein sensing using amphiphilic supramolecular assemblies

Supplementary files

Article information

Article type
Communication
Submitted
24 sept. 2021
Accepted
06 nov. 2021
First published
08 nov. 2021

Chem. Commun., 2021,57, 12828-12831

Multichannel dual protein sensing using amphiphilic supramolecular assemblies

J. Gao, T. Prachyathipsakul and S. Thayumanavan, Chem. Commun., 2021, 57, 12828 DOI: 10.1039/D1CC05407D

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