Issue 68, 2021

Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites

Abstract

Photoinduced phosphonation of aryl triflates with trialkyl phosphites via a tandem single-electron-transfer, C–O bond cleavage and Arbuzov rearrangement process in the absence of transition-metal and external photosensitizer is reported herein. The protocol features good functional group compatibility and mild reaction conditions, providing various aryl phosphates in good to high yields. Furthermore, this strategy allows the late-stage phosphonation of complex and biologically active compounds.

Graphical abstract: Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites

Supplementary files

Article information

Article type
Communication
Submitted
30 juin 2021
Accepted
27 juil. 2021
First published
29 juil. 2021

Chem. Commun., 2021,57, 8429-8432

Photoinduced transition-metal and external photosensitizer free cross-coupling of aryl triflates with trialkyl phosphites

Q. Dou, L. Geng, B. Cheng, C. Li and H. Zeng, Chem. Commun., 2021, 57, 8429 DOI: 10.1039/D1CC03496K

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