Issue 5, 2021
From the journal:

Analyst

Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity†

Min Wen,a   Chen Li,a   Mengyuan Zhang,a   Yan Sun,a   Fengming Liu,b   Xiaoyan Cui ORCID logo *a  and  Yongkui Shana  

* Corresponding authors

a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P.R. China
E-mail: xycui@chem.ecnu.edu.cn

b National Center for Protein Science Shanghai, No.333 Haike Road, Pudong New District, Shanghai 200120, China

Abstract

A series of fluorescent molecular rotors, acridinium benzoates (Acr-A,B,C,D), were designed for ratiometrically monitoring cellular viscosity. High sensitivity to viscosity was observed in probe Acr-A with an insignificant steric effect in the acridinium nitrogen. Acr-A was employed to distinguish cancer cells from normal cells and track the dynamics of viscosity during cellular apoptosis.

Graphical abstract: Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

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Article information

DOI
https://doi.org/10.1039/D0AN02321C
Article type
Communication
Submitted
03 déc. 2020
Accepted
11 janv. 2021
First published
11 janv. 2021

Analyst, 2021,146, 1538-1542

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

M. Wen, C. Li, M. Zhang, Y. Sun, F. Liu, X. Cui and Y. Shan, Analyst, 2021, 146, 1538 DOI: 10.1039/D0AN02321C

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