Issue 77, 2020

Autocatalytic DNAzyme assembly for amplified intracellular imaging

Abstract

The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.

Graphical abstract: Autocatalytic DNAzyme assembly for amplified intracellular imaging

Supplementary files

Article information

Article type
Communication
Submitted
01 août 2020
Accepted
02 sept. 2020
First published
02 sept. 2020

Chem. Commun., 2020,56, 11410-11413

Autocatalytic DNAzyme assembly for amplified intracellular imaging

K. Gong, Q. Wu, H. Wang, S. He, J. Shang and F. Wang, Chem. Commun., 2020, 56, 11410 DOI: 10.1039/D0CC05257D

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