Issue 7, 2019
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed arene amination in pure aqueous ammonia†

Mio Takagi,‡a   Ayako Watanabe,‡a   Shigeo Murataa  and  Ryo Takita ORCID logo *a  

* Corresponding authors

a One-stop Sharing Facility Center for Future Drug Discoveries, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, Japan
E-mail: takita@mol.f.u-tokyo.ac.jp

Abstract

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed. The reaction pathway via a Cu(I)/Cu(III) mechanism is proposed based on the results of control experiments as well as DFT calculations.

Graphical abstract: Copper-catalyzed arene amination in pure aqueous ammonia

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Article information

DOI
https://doi.org/10.1039/C8OB02708K
Article type
Communication
Submitted
31 oct. 2018
Accepted
16 nov. 2018
First published
19 nov. 2018

Org. Biomol. Chem., 2019,17, 1791-1795

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Copper-catalyzed arene amination in pure aqueous ammonia

M. Takagi, A. Watanabe, S. Murata and R. Takita, Org. Biomol. Chem., 2019, 17, 1791 DOI: 10.1039/C8OB02708K

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