Issue 7, 2019

Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization

Abstract

The rhodium-catalyzed arylative cyclization of enone tethered-cyclohexadienones has been developed with high efficiency, thus providing cis-fused bicyclic enones in good yields and with excellent diastereoselectivities. Furthermore, this mild transformation has a broad range of substrate scope and excellent functional group tolerance. In addition, bicyclic products have an enone functionality, which can be a synthetically valuable handle for further transformations.

Graphical abstract: Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization

Supplementary files

Article information

Article type
Paper
Submitted
15 sept. 2018
Accepted
04 oct. 2018
First published
05 oct. 2018

Org. Biomol. Chem., 2019,17, 1937-1946

Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization

S. B. Jadhav, S. B. Thopate, J. B. Nanubolu and R. Chegondi, Org. Biomol. Chem., 2019, 17, 1937 DOI: 10.1039/C8OB02284D

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