Issue 48, 2018

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Abstract

Using a highly effective heterologous expression system, the YM-216391 (1) biosynthetic gene cluster was engineered to yield aurantizolicin (2) and the hybrid compound 3. Both of these compounds were isolated and fully structurally characterised and the bioactivity was evaluated. The results indicate that compound 3 exhibits significantly improved antitumor activity.

Graphical abstract: Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Supplementary files

Article information

Article type
Communication
Submitted
28 oct. 2018
Accepted
22 nov. 2018
First published
27 nov. 2018

Org. Biomol. Chem., 2018,16, 9373-9376

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Z. Pei, M. Yang, L. Li, X. Jian, Y. Yin, D. Li, H. Pan, Y. Lu, W. Jiang and G. Tang, Org. Biomol. Chem., 2018, 16, 9373 DOI: 10.1039/C8OB02665C

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