Issue 27, 2015

Cascade catalysis – strategies and challenges en route to preparative synthetic biology

Abstract

Nature's smartness and efficient assembling cascade type reactions inspired biologists and chemists all around the world. Tremendous effort has been directed towards the understanding and mimicking of such networks. In recent years considerable progress has been made in developing multistep one-pot reactions combining either advantage of chemo-, regio-, and stereoselectivity of biocatalysts or promiscuity and productivity of chemocatalysts. In this context several concepts, inspired by different disciplines (biocatalysis, metabolic engineering, synthetic chemistry, and material science), have been evolved. This review will focus on major contributions in the field of cascade reactions over the last three years.

Graphical abstract: Cascade catalysis – strategies and challenges en route to preparative synthetic biology

Article information

Article type
Feature Article
Submitted
03 nov. 2014
Accepted
10 déc. 2014
First published
10 déc. 2014

Chem. Commun., 2015,51, 5798-5811

Author version available

Cascade catalysis – strategies and challenges en route to preparative synthetic biology

J. Muschiol, C. Peters, N. Oberleitner, M. D. Mihovilovic, U. T. Bornscheuer and F. Rudroff, Chem. Commun., 2015, 51, 5798 DOI: 10.1039/C4CC08752F

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